Against the backdrop of the European Union's efforts to regulate the class of per- and polyfluoroalkyl substances (PFAS), we invite stakeholders from science, industry, authorities, and other relevant institutes to jointly discuss the contentious issues surrounding PFAS and how to address them in the future.We aim to explore this controversial topic from multiple perspectives at the conference and foster a well-informed professional dialogue. To this end, the invited speakers will highlight various applications where PFAS may be avoidable, substitutable, or indispensable.